Lyophosome™ made from Unsaturated Phosphatidylcholine (PC)

Size Cat no Lipid composition Price Quantity Subtotal
5-ml LUP-501 100% 14:1 (Δ9-Cis) PC $950.00
$0.00
5-ml LUP-502 100% 14:1 (Δ9-Trans) PC $950.00
$0.00
5-ml LUP-503 100% 16:1 (Δ9-Cis) PC $950.00
$0.00
5-ml LUP-504 100% 16:1 (Δ9-Trans) PC $950.00
$0.00
5-ml LUP-505 100% 18:1 (Δ6-Cis) PC $950.00
$0.00
5-ml LUP-506 100% 18:1 (Δ9-Cis) PC (DOPC) $950.00
$0.00
5-ml LUP-507 100% 18:1 (Δ9-Trans) PC $950.00
$0.00
5-ml LUP-508 100% 18:2 (Cis) PC (DLPC) $950.00
$0.00
5-ml LUP-509 100% 20:1 (Cis) PC $950.00
$0.00
5-ml LUP-510 100% 22:1 (Cis) PC $950.00
$0.00
5-ml LUP-511 100% 24:1 (Cis) PC $950.00
$0.00
5-ml LUP-512 100% 16:0-18:1 PC (POPC) $950.00
$0.00
5-ml LUP-513 100% 16:0-18:2 PC $950.00
$0.00
5-ml LUP-514 100% 16:0-20:4 PC $950.00
$0.00
5-ml LUP-515 100% 18:0-18:1 PC $950.00
$0.00
5-ml LUP-516 100% 18:0-18:2 PC $950.00
$0.00
5-ml LUP-517 100% 18:0-20:4 PC $950.00
$0.00
5-ml LUP-518 100% 18:1-14:0 PC $950.00
$0.00
5-ml LUP-519 100% 18:1-16:0 PC $950.00
$0.00
5-ml LUP-520 100% 18:1-18:0 PC $950.00
$0.00
Bulk & Custom sizes Checkout
Cart Total $0.00

Download Product Insert Download Safety Datasheet (SDS)

Formulation Information

Lyophosome™ made from Unsaturated Phosphatidylcholine (PC)

For more information on the lipid composition of the liposomes mentioned above click here.

Buffer, Lyoprotectant and Liposome Size  
Buffer Lyophilized Phosphate Buffered Saline*
pH7.4 (after hydration)
LyoprotectantTrehalose
Liposome size100 nm (after hydration)
*If you prefer different buffers or deionized water, please specify in your order.

Technical Notes

  • Due to very rapid hydrolysis of adenosine triphosphate (ATP), ATP liposome (ATPsome®) formulations are all freeze dried.
  • Leftover liposomes in liquid form that are made after hydration of the lyophilized proliposome formulation can not be used or kept in refrigerator for future use due to rapid hydrolysis on ATP.
  • Liposomes are formed upon hydration of the lyophilized formulation. Very large percentage of ATP molecules will remain encapsulated inside the liposomes but some percentage will be free and in non-encapsulated form after hydration of the freeze dried formulation. Free ATP molecules usually does not have any negative impact upon injection of the formulation to the animal or upon adding the formulation to the cell cultures.
  • Trehalose is used as a lyoprotectant in all freeze dried liposome formulation. The size distribution after hydration of the freeze dried formulation will be around 100 nm.
  • Freeze dried liposomes should be kept at  -40 °C or -80 °C.

Appearance

Non Fluorescent ATP proliposome (ATPsome®) is white lyophilized powder. Fluorescent ATPsome® depending on the color of the dye will be slightly colored. Fluorescent ATPsome® containing NBD fluorescent dye is yellow and fluorescent ATPsome® containing Rhodamine is pink. The lyophilized formulation is packaged in an amber vial. Liposomes are formed upon adding water to the freeze dried proliposomes. Non fluorescent liposomes will form a white translucent liposome formulation and fluorescent liposomes will form colored translucent liposomes, depending on the color of the fluorescent dye.

Ordering/Shipping Information

  • All proliposome lyophilized formulations are shipped on dry ice at -78.5 °C in insulated packages using overnight shipping or international express shipping.
  • Lyophilized proliposomes should be frozen at -40 °C or -80 °C. Upon adding water to proliposomes, liposomes are formed. These liposomes should be used immediately due to very rapid hydrolysis of ATP.
  • Clients who order from outside of the United States of America are responsible for their government import taxes and customs paperwork. Encapsula NanoSciences is NOT responsible for importation fees to countries outside of the United States of America.
  • We strongly encourage the clients in Japan, Korea, Taiwan and China to order via a distributor. Tough customs clearance regulations in these countries will cause delay in custom clearance of these perishable formulations if ordered directly through us. Distributors can easily clear the packages from customs. To see the list of the distributors click here.
  • Clients ordering from universities and research institutes in Australia should keep in mind that the liposome formulations are made from synthetic material and the formulations do not require a “permit to import quarantine material”. Liposomes are NOT biological products.
  • If you would like your institute’s FedEx or DHL account to be charged for shipping then please provide the account number at the time of ordering.
  • Encapsula NanoSciences has no control over delays due to inclement weather or Customs clearance delays. You will receive a FedEx or DHL tracking number once your order is confirmed. Contact FedEx or DHL in advance and make sure that the paperwork for customs is done on time. All subsequent shipping inquiries should be directed to Federal Express or DHL.

Storage and Shelf Life

Storage

ATP proliposome (ATPsome®) products should always be stored in a freezer at at -40 °C or -80 °C. Upon adding water to proliposomes, liposomes are formed. These liposomes should be used immediately due to very rapid hydrolysis of ATP. The leftover liposomes in liquid form that are not immediately used can be discarded safely in drain.

Shelf Life

ATP proliposome (ATPsome®) made on order. The batch that is shipped is manufactured the same day. It is advised to use the products within 6 months of the manufacturing date.

References and background reading

1. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 Jul 28;535(7613):551-5.

2. Dvoriantchikova G, Barakat DJ, Hernandez E, Shestopalov VI, Ivanov D. Liposome-delivered ATP effectively protects the retina against ischemia-reperfusion injury. Molecular vision. 2010;16:2882.

3. MacCarthy CM, Notario V. The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family. International journal of oncology. 2013 Oct 1;43(4):1244-52.

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