Lyophosome™ made from Natural Phosphatidylserine (PS) Lipid Extracts

Size Cat no Lipid composition Liposome Size Price Quantity Subtotal
10-mg LPS-601 100% Brain PS $950.00
$0.00
10-mg LPS-602 100% Soy PS $950.00
$0.00
10-mg LPS-603 Brain PS:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LPS-604 Soy PS:Cholesterol (70:30 molar ratio) $950.00
$0.00
Bulk & Custom sizes Checkout
Cart Total $0.00

Description

Lyophosome™-Natural Phosphatidylserine (PS) extract catalog is composed of four liposomes made from phosphatidylserine (PS) lipids that are made from natural lipids that are extracted from either brain or soybean. Adding 30% cholesterol makes the liposomes serum stable and is necessary when the liposomes are used in the presence of serum.

These liposomes are all anionic due to the negative charge of phosphatidylserine.

Brain phosphatidylserine (PS) is composed of both saturated and unsaturated lipids. Brain PS contains much larger percentage of saturated lipids compare to Soy PS. Brain PS is mainly composed of four lipids: 42% of 18:0 lipid, 30% of 18:1 lipid, 2% of 20:4 lipid and 11% of 22:6 lipid.

Soy PS is composed of both saturated and unsaturated lipids. Soy PS contains more unsaturated lipids. Soy PC is mainly composed of 5 lipids: 10% of 16:0 lipid, 3% of 18:0 lipid, 12% of 18:1 lipid, 68% of 18:2 lipid, and 7% of 18:3 lipid.

Lyophosome™ product catalog is composed of a large selection of freeze-dried liposomes with various types of lipids and wide range of zeta potentials and different properties. Lyophosome™ products should be used by scientists who understand liposome formulation and have the proper equipment to check the size, separate non-encapsulated drugs and do the proper assays. Freeze-dried liposomes cannot be used blindly.

Download Product Insert Download Safety Datasheet (SDS)

Formulation Information

Lyophosome™ made from Natural Phosphatidylserine (PS) Lipid Extracts

For more information on the lipid composition of the liposomes mentioned above click here.

Buffer, Lyoprotectant and Liposome Size  
BufferDeionized water*
LyoprotectantTrehalose
Liposome size100 nm (after hydration)
*If you prefer a different buffer please specify in your order.

Technical Notes

  • Liposomes are unilamellar and sized to 100 nm. If you need them to be made in another size, then you should mention that at the time of ordering. Unilamellar liposomes can be made in 50 nm and 200 nm sizes. Liposomes that are larger than 200 nm are multilamellar structure.
  • Liposomes are made in PBS buffer at pH 7.4 but it can be made in any other buffer of your choice. You can specify your buffer at the time of ordering.
  • Liposomes are made in degassed buffer that is purged with argon to avoid oxidation of the unsaturated phospholipids.
  • Liposomes are made under sterile condition.
  • Liposomes are unilamellar and therefore due to their small size they will not settle in the bottom of the vial.
  • If you need to take multiple aliquots out of the vial, for use over a period of time, then it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product.
  • Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size the liposomes particles.

Appearance

Lyophosome™ is a white lyophilized powder. Liposomes are formed upon adding water to the freeze-dried proliposomes and the appearance of the formulation will be white translucent liquid.

Ordering/Shipping Information

  • All liposome based formulations are shipped on blue ice at 4°C in insulated packages using overnight shipping or international express shipping.
  • Liposomes should NEVER be frozen. Ice crystals that form in the lipid membrane can rupture the membrane and change the size of the liposomes. Liposomes in liquid form should always be kept in the refrigerator.
  • Clients who order from outside of the United States of America are responsible for their government import taxes and customs paperwork. Encapsula NanoSciences is NOT responsible for importation fees to countries outside of the United States of America.
  • We strongly encourage the clients in Japan, Korea, Taiwan and China to order via a distributor. Tough customs clearance regulations in these countries will cause delay in custom clearance of these perishable formulations if ordered directly through us. Distributors can easily clear the packages from customs. To see the list of the distributors click here.
  • Clients ordering from universities and research institutes in Australia should keep in mind that the liposome formulations are made from synthetic material and the formulations do not require a “permit to import quarantine material”. Liposomes are NOT biological products.
  • If you would like your institute’s FedEx or DHL account to be charged for shipping, then please provide the account number at the time of ordering.
  • Encapsula NanoSciences has no control over delays due to inclement weather or customs clearance delays. You will receive a FedEx or DHL tracking number once your order is confirmed. Contact FedEx or DHL in advance and make sure that the paperwork for customs is done on time. All subsequent shipping inquiries should be directed to Federal Express or DHL.

Storage and Shelf Life

Storage

Lyophosome™ products should always be stored in a freezer at -20°C. Upon adding water to proliposomes, liposomes are formed. 

Shelf Life

Lyophosome™ is made on order. The batch that is shipped is manufactured on the same day. It is advised to use the products within 12 months of the manufacturing date.

References and background reading

1. Crowe LM, Crowe JH, Rudolph A, Womersley C, Appel L. Preservation of freeze-dried liposomes by trehalose. Archives of biochemistry and biophysics. 1985 Oct 1;242(1):240-7.

2. Crommelin DJ, Van Bommel EM. Stability of liposomes on storage: freeze dried, frozen or as an aqueous dispersion. Pharmaceutical research. 1984 Jul 1;1(4):159-63.

3. van Winden EC, Crommelin DJ. Short term stability of freeze-dried, lyoprotected liposomes. Journal of controlled release. 1999 Mar 8;58(1):69-86.

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