Lipid Composition for PEGylated Phosphatidylglycerol (PG)-based ATP Liposomes (ATPsome®-PEG)

Lipid Composition for APGG-201Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.9750.7865
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.16 mg/vial100
Lipid Composition for APGG-202Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.9000.7260
1,2-dioleoyl-sn-glycero-3-phosphocholine0.0750.065
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.16 mg/vial100
Lipid Composition for APGG-203Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.9000.7250
1,2-dioleoyl-sn-glycero-3-phosphocholine0.0750.0615
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.16 mg/vial100
Lipid Composition for APGG-204Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.6000.4840
1,2-dioleoyl-sn-glycero-3-phosphocholine0.3750.2925
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.15 mg/vial100
Lipid Composition for APGG-205Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.4500.3630
1,2-dioleoyl-sn-glycero-3-phosphocholine0.5250.4135
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.15 mg/vial100
Lipid Composition for APGG-206Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.3000.2420
1,2-dioleoyl-sn-glycero-3-phosphocholine0.6750.5345
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.15 mg/vial100
Lipid Composition for APGG-207Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.1500.1210
1,2-dioleoyl-sn-glycero-3-phosphocholine0.8250.6555
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.15 mg/vial100
Lipid Composition for APGG-208Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.0750.065
1,2-dioleoyl-sn-glycero-3-phosphocholine0.9000.7160
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial1.15 mg/vial100
Lipid Composition for APGG-209Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.0375
0.03
2.5
1,2-dioleoyl-sn-glycero-3-phosphocholine0.93750.7462.5
Cholesterol0.45000.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750
0.215
Total1.5000 µmol/vial1.15 mg/vial100
Lipid Composition for APGG-210Amount (µmol/vial)Amount (mg/vial)Molar Ratio Percentage
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)0.015
0.01
1
1,2-dioleoyl-sn-glycero-3-phosphocholine0.9600.7564
Cholesterol0.4500.1730
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)- 2000] (ammonium salt)0.0750.215
Total1.500 µmol/vial 1.15 mg/vial100
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