Lyophosome™ made from Saturated Phosphatidylcholine (PC)

Size Cat no Lipid composition Price Quantity Subtotal
10-mg LHP-501 100% 14:0 PC (DMPC) $950.00
$0.00
10-mg LHP-502 100% 15:0 PC $950.00
$0.00
10-mg LHP-503 100% 16:0 PC (DPPC) $950.00
$0.00
10-mg LHP-504 100% 17:0 PC $950.00
$0.00
10-mg LHP-505 100% 18:0 PC (DSPC) $950.00
$0.00
10-mg LHP-506 100% 19:0 PC $950.00
$0.00
10-mg LHP-507 100% 20:0 PC $950.00
$0.00
10-mg LHP-508 100% 21:0 PC $950.00
$0.00
10-mg LHP-509 100% 22:0 PC (DBPC) $950.00
$0.00
10-mg LHP-510 100% 23:0 PC $950.00
$0.00
10-mg LHP-511 100% 24:0 PC $950.00
$0.00
10-mg LHP-512 100% 14:0-16:0 PC $950.00
$0.00
10-mg LHP-513 100% 14:0-18:0 PC $950.00
$0.00
10-mg LHP-514 100% 16:0-14:0 PC $950.00
$0.00
10-mg LHP-515 100% 16:0-18:0 PC $950.00
$0.00
10-mg LHP-516 14:0 PC (DMPC):Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-517 15:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-518 16:0 PC (DPPC):Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-519 17:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-520 18:0 PC (DSPC):Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-521 19:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-522 20:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-523 21:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-524 22:0 PC (DBPC):Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-525 23:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
10-mg LHP-526 24:0 PC:Cholesterol (70:30 molar ratio) $950.00
$0.00
Bulk & Custom sizes Checkout
Cart Total $0.00

Download Product Insert Download Safety Datasheet (SDS)

Formulation Information

Lyophosome™ made from Saturated Phosphatidylcholine (PC)

For more information on the lipid composition of the liposomes mentioned above click here.

Buffer, Lyoprotectant and Liposome Size  
Buffer Lyophilized Phosphate Buffered Saline*
pH7.4 (after hydration)
LyoprotectantTrehalose
Liposome size100 nm (after hydration)
*If you prefer different buffers or deionized water, please specify in your order.

Technical Notes

  • Liposomes are formed upon hydration of the lyophilized formulation. If the lyophilized liposomes are hydrated with solution containing a water soluble drug then a large percentage of the drug will stay outside of the liposomes and in non-encapsulated form. It is advised to use a micro dialysis cassette or a spin column using the right side beads (depending on the size of your drug) and separate the drug encapsulated liposomes from free drug and perform the drug assay in order to calculate the encapsulation efficiency. 
  • Lyophilized liposomes are mainly recommended to be used with drugs that have a short life in aqueous solution mainly due to hydrolysis. After adding the solution of the drug to lyophilized liposomes, the liposomes should be used immediately.
  • Lyophosome™ products should be used by scientists who understand liposome formulation and have the proper equipment in order to check the size, separate the non-encapsulated drug and do the proper assays.
  • Trehalose is used as a lyoprotectant in all freeze dried liposome formulation. The size distribution after hydration of the freeze dried formulation will be around 100 nm.
  • Freeze dried liposomes should be kept at -40 °C or -80 °C.

Appearance

Lyophosome™ is a white lyophilized powder. Liposomes are formed upon adding water to the freeze dried proliposomes and the appearance of the formulation will be white translucent liquid.

Ordering/Shipping Information

  • All proliposome lyophilized formulations are shipped on dry ice at -78.5 °C in insulated packages using overnight shipping or international express shipping.
  • Lyophilized proliposomes should be frozen at -40 °C or -80 °C. Upon adding water to proliposomes, liposomes are formed.
  • Clients who order from outside of the United States of America are responsible for their government import taxes and customs paperwork. Encapsula NanoSciences is NOT responsible for importation fees to countries outside of the United States of America.
  • We strongly encourage the clients in Japan, Korea, Taiwan and China to order via a distributor. Tough customs clearance regulations in these countries will cause delay in custom clearance of these perishable formulations if ordered directly through us. Distributors can easily clear the packages from customs. To see the list of the distributors click here.
  • Clients ordering from universities and research institutes in Australia should keep in mind that the liposome formulations are made from synthetic material and the formulations do not require a “permit to import quarantine material”. Liposomes are NOT biological products.
  • If you would like your institute’s FedEx or DHL account to be charged for shipping then please provide the account number at the time of ordering.
  • Encapsula NanoSciences has no control over delays due to inclement weather or customs clearance delays. You will receive a FedEx or DHL tracking number once your order is confirmed. Contact FedEx or DHL in advance and make sure that the paperwork for customs is done on time. All subsequent shipping inquiries should be directed to Federal Express or DHL.

Storage and Shelf Life

Storage

Lyophosome™ products should always be stored in a freezer at at -40 °C or -80 °C. Upon adding water to proliposomes, liposomes are formed. 

Shelf Life

Lyophosome™ is made on order. The batch that is shipped is manufactured on the same day. It is advised to use the products within 6 months of the manufacturing date.

References and background reading

1. Crowe LM, Crowe JH, Rudolph A, Womersley C, Appel L. Preservation of freeze-dried liposomes by trehalose. Archives of biochemistry and biophysics. 1985 Oct 1;242(1):240-7.

2. Crommelin DJ, Van Bommel EM. Stability of liposomes on storage: freeze dried, frozen or as an aqueous dispersion. Pharmaceutical research. 1984 Jul 1;1(4):159-63.

3. van Winden EC, Crommelin DJ. Short term stability of freeze-dried, lyoprotected liposomes. Journal of controlled release. 1999 Mar 8;58(1):69-86.

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