| Lipid Composition for GEN-7000 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 100 |
| Lipid Composition for GEN-7001 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 50 |
| Cholesterol | 2 | 50 |
| Lipid Composition for GEN-7002 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt (DOTAP) | 2 | 50 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) | 2 | 50 |
| Lipid Composition for GEN-7036 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 44.5 |
| Cholesterol | 1.5 | 33.3 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) | 1 | 22.2 |
| Lipid Composition for GEN-7008 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 99.9 |
| 1,1'-dioctadecyl-3,3,3',3'-etramethylindocarbocyanine perchlorate (DiI) | 0.002 | 0.1 |
| Lipid Composition for GEN-7007 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 99.5 |
| 3,3'-dilinoleyloxacarbocyanine perchlorate (DiO) | 0.01 | 0.5 |
| Lipid Composition for GEN-7003 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 49.75 |
| Cholesterol | 2 | 49.75 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2- 1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD-DOPE) | 0.02 | 0.5 |
| Lipid Composition for GEN-7004 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 49.75 |
| Cholesterol | 2 | 49.75 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod-PE) | 0.02 | 0.5 |
| Lipid Composition for GEN-7005 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 49.75 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) | 2 | 49.75 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2- 1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD-DOPE) | 0.02 | 0.5 |
| Lipid Composition for GEN-7006 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 49.75 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) | 2 | 49.75 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod-PE) | 0.02 | 0.5 |
| Lipid Composition for GEN-7037 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 44 |
| Cholesterol | 1.5 | 33 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) | 1.02 | 22.5 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2- 1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD-DOPE) | 0.023 | 0.5 |
| Lipid Composition for GEN-7038 | Concentration (mM) | Molar Ratio Percentage |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (DOTAP) | 2 | 44 |
| Cholesterol | 1.5 | 33 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) | 1.02 | 22.5 |
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod-PE) | 0.023 | 0.5 |
