Lipid composition for fluorescent PEGylated phosphatidylserine PS based ATP Liposomes (ATPsome-PEG)

Lipid Composition for FASG-201
Amount (µmol/vial)Amount (mg/vial) Molar Ratio Percentage
L-alpha-phosphatidylserine0.975
0.79
65
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.18 mg/vial100
Lipid Composition for FASG-202

Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.900
0.7360
L-alpha-phosphatidylcholine0.0750.06
5
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.18 mg/vial100
Lipid Composition for FASG-203
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.7500.6050
L-alpha-phosphatidylcholine0.2250.1715
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.16 mg/vial100
Lipid Composition for FASG-204
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.6000.4840
L-alpha-phosphatidylcholine0.3750.2925
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.16 mg/vial100
Lipid Composition for FASG-205
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.4500.3630
L-alpha-phosphatidylcholine0.5250.4135
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.01
1
Total1.500 umol/vial1.16 mg/vial100
Lipid Composition for FASG-206
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.3000.2420
L-alpha-phosphatidylcholine0.6750.52
45
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.15 mg/vial100
Lipid Composition for FASG-207
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.1500.1210
L-alpha-phosphatidylcholine0.8250.6455
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.015
0.011
Total1.500 umol/vial1.15 mg/vial100
Lipid Composition for FASG-208
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.0750.065
L-alpha-phosphatidylcholine0.9000.7060
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.15 mg/vial100
Lipid Composition for FASG-209
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.03750.032.5
L-alpha-phosphatidylcholine0.93750.7362.5
Cholesterol0.43500.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.07500.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.01500.011
Total1.5000 umol/vial1.15 mg/vial100
Lipid Composition for FASG-210
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.0150.01
1
L-alpha-phosphatidylcholine0.9600.7464
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD PE)0.0150.011
Total1.500 umol/vial1.14 mg/vial100
Lipid Composition for FASG-211
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.9750.7965
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)
0.0150.021
Total1.500 mg/vial1.19 mg/vial100
Lipid Composition for FASG-212
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.9000.7360
L-alpha-phosphatidylcholine0.0750.065
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.19100
Lipid Composition for FASG-213
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.7500.6050
L-alpha-phosphatidylcholine0.2250.1715
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)
0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.17 mg/vial100
Lipid Composition for FASG-214
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.6000.4840
L-alpha-phosphatidylcholine0.3750.2925
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.17 mg/vial100
Lipid Composition for FASG-215
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.4500.3630
L-alpha-phosphatidylcholine0.5250.4135
Cholesterol0.435
0.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.17 mg/vial100
Lipid Composition for FASG-216

Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.3000.2420
L-alpha-phosphatidylcholine0.6750.52
45
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.16 mg/vial100
Lipid Composition for FASG-217
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.1500.1210
L-alpha-phosphatidylcholine0.8250.6455
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.16 mg/vial100
Lipid Composition for FASG-218
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.0750.065
L-alpha-phosphatidylcholine0.9000.7060
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.16 mg/vial100
Lipid Composition for FASG-219
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.03750.032.5
L-alpha-phosphatidylcholine0.93750.7362.5
Cholesterol0.43500.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.07500.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.01500.021
Total1.5000 umol/vial1.16 mg/vial100
Lipid Composition for FASG-220
Amount (µmol/vial)
Amount (mg/vial)
Molar Ratio Percentage
L-alpha-phosphatidylserine0.0150.011
L-alpha-phosphatidylcholine0.9600.7464
Cholesterol0.4350.1729
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)0.0750.215
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE)0.0150.021
Total1.500 umol/vial1.15 mg/vial100
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