Lipid Composition for PEGylated Phosphatidylserine (PS)-based ATP Liposomes (ATPsome®-PEG)

Lipid Composition for APSG-201	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.98	0.805	65
Cholesterol	0.45	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.210	5
Total	1.5 µmol/vial	1.189 mg/vial	100

Lipid Composition for APSG-202	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.9	0.743	60
L-alpha-phosphatidylcholine	0.075	0.059	5
Cholesterol	0.45	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.210	5
Total	1.5 µmol/vial	1.186 mg/vial	100

Lipid Composition for APSG-203	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.75	0.62	50
L-alpha-phosphatidylcholine	0.225	0.177	15
Cholesterol	0.451	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.210	5
Total	1.5 µmol/vial	1.181 mg/vial	100

Lipid Composition for APSG-204	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.6	0.495	40
L-alpha-phosphatidylcholine	0.375	0.295	25
Cholesterol	0.45	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.210	5
Total	1.5 µmol/vial	1.174 mg/vial	100

Lipid Composition for APSG-205	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.451	0.372	30
L-alpha-phosphatidylcholine	0.526	0.414	35
Cholesterol	0.451	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.210	5
Total	1.5 µmol/vial	1.170 mg/vial	100

Lipid Composition for APSG-206	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.301	0.248	20
L-alpha-phosphatidylcholine	0.676	0.532	45
Cholesterol	0.451	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.211	5
Total	1.5 µmol/vial	1.165 mg/vial	100

Lipid Composition for APSG-207	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.15	0.124	10
L-alpha-phosphatidylcholine	0.827	0.650	55
Cholesterol	0.451	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.211	5
Total	1.5 µmol/vial	1.159 mg/vial	100

Lipid Composition for APSG-208	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.075	0.0622	5
L-alpha-phosphatidylcholine	0.90	0.711	60
Cholesterol	0.45	0.175	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.211	5
Total	1.5 µmol/vial	1.159 mg/vial	100

Lipid Composition for APSG-209	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.038	0.031	2.5
L-alpha-phosphatidylcholine	0.94	0.738	62.5
Cholesterol	0.45	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.210	5
Total	1.5 µmol/vial	1.153 mg/vial	100

Lipid Composition for APSG-210	Amount (µmol/vial)	Amount (mg/vial)	Molar Ratio Percentage
L-alpha-phosphatidylserine	0.015	0.0124	1
L-alpha-phosphatidylcholine	0.96	0.756	64
Cholesterol	0.45	0.174	30
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)	0.075	0.211	5
Total	1.5 µmol/vial	1.153 mg/vial	100