Lipid Composition for Cationic Liposome Containing DC-Cholesterol (Plain and Fluorescent)

Lipid Composition for GEN-7027Concentration (mM)Molar Ratio Percentage
3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)		250
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)250
Lipid Composition for GEN-7028Concentration (mM)Molar Ratio Percentage
3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)		233.3
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)4.0166.7
Lipid Composition for GEN-7029Concentration (mM)Molar Ratio Percentage
3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)		249.75
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)249.75
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-
1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD-DOPE)		0.020.5
Lipid Composition for GEN-7030Concentration (mM)Molar Ratio Percentage
3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)		249.75
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)249.75
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine
rhodamine B sulfonyl) (ammonium salt) (Rhod-PE)		0.020.5
Lipid Composition for GEN-7031Concentration (mM)Molar Ratio Percentage
3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)		233.3
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)3.9866.2
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-
1,3-benzoxadiazol-4-yl) (ammonium salt) (NBD-DOPE)		0.030.5
Lipid Composition for GEN-7032Concentration (mM)Molar Ratio Percentage
3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol
hydrochloride (DC-Chol)		233.3
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)3.9866.2
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine
rhodamine B sulfonyl) (ammonium salt) (Rhod-PE)		0.030.5
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