Clodronate Liposomes

Clodronate liposome literature database: website which will contain comprehensive information about Clodronate liposomes and macrophage depletion. In the mean time the following database can be used which summarizes all the Clodronate liposome research papers from 1994 to 2012.

How to order

To view various types of macrophage depletion kits and to place an order please visit:


Lehenkari PP, Kellinsalmi M, Näpänkangas JP, Ylitalo KV, Mönkkönen J, Rogers MJ, Azhayev A,Väänänen HK, and Hassinen, I.E. (2002) Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Molecular Pharmacology 62:1255-1262.

Frith, J, Mönkkönen J, Auriola, S, Mönkkönen H, and Rogers MJ (2001) The molecular mechanism of action of the antiresorptive and anti-inflammatory drug clodronate. Arthritis and Rheumatism 44:2201-2210.

Frith, J, Mönkkönen J, Blackburn GM, Russell RGG, and Rogers MJ (1997) Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5';-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. Journal of Bone and Mineral Research 12:1358-1367.